Ki Summary

Reaction Details

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Target

Orotidine 5'-phosphate decarboxylase

Ligand

BDBM83786

Substrate/Competitor

n/a

Meas. Tech.

Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter

EC50

>59585±n/a nM

Citation

PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Assay Method

Orotidine 5'-phosphate decarboxylase

Name:

Orotidine 5'-phosphate decarboxylase

Synonyms:

FXN frataxin | PYRF_ASPNG | pyrA | pyrG

Type:

Enzyme Catalytic Domain

Mol. Mass.:

30195.13

Organism:

Aspergillus niger

Description:

gi_2395

Residue:

277

Sequence:

MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAV
IKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHI
INCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKY
KNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGA
DFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN

BDBM83786

n/a

Name

BDBM83786

Synonyms:

MLS000683363 | N'-(2-bromo-3-phenyl-2-propen-1-ylidene)-3-(2-furyl)-1H-pyrazole-5-carbohydrazide | N-[[(Z)-2-bromanyl-3-phenyl-prop-2-enylidene]amino]-5-(furan-2-yl)-1H-pyrazole-3-carboxamide | N-[[(Z)-2-bromo-3-phenyl-prop-2-enylidene]amino]-5-(2-furyl)-1H-pyrazole-3-carboxamide | N-[[(Z)-2-bromo-3-phenylprop-2-enylidene]amino]-5-(2-furanyl)-1H-pyrazole-3-carboxamide | N-[[(Z)-2-bromo-3-phenylprop-2-enylidene]amino]-5-(furan-2-yl)-1H-pyrazole-3-carboxamide | SMR000267829 | cid_1359975

Type

Small organic molecule

Emp. Form.

C17H13BrN4O2

Mol. Mass.

385.215

SMILES

BrC(C=NNC(=O)c1cc(n[nH]1)-c1ccco1)=Cc1ccccc1 |w:3.3,17.19|

Structure