Ki Summary

Reaction Details

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Target

Orotidine 5'-phosphate decarboxylase

Ligand

BDBM83824

Substrate/Competitor

n/a

Meas. Tech.

Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter

EC50

>59642±n/a nM

Citation

PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Assay Method

Orotidine 5'-phosphate decarboxylase

Name:

Orotidine 5'-phosphate decarboxylase

Synonyms:

FXN frataxin | PYRF_ASPNG | pyrA | pyrG

Type:

Enzyme Catalytic Domain

Mol. Mass.:

30195.13

Organism:

Aspergillus niger

Description:

gi_2395

Residue:

277

Sequence:

MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAV
IKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHI
INCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKY
KNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGA
DFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN

BDBM83824

n/a

Name

BDBM83824

Synonyms:

MLS002182868 | N-[2-(dimethylamino)-2-phenyl-ethyl]-2-[(3-methyl-4-oxidanylidene-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl)sulfanyl]ethanamide | N-[2-(dimethylamino)-2-phenyl-ethyl]-2-[(4-keto-3-methyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-2-yl)thio]acetamide | N-[2-(dimethylamino)-2-phenylethyl]-2-[(3-methyl-4-oxo-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl)sulfanyl]acetamide | N-[2-(dimethylamino)-2-phenylethyl]-2-[(3-methyl-4-oxo-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl)thio]acetamide | SMR001271898 | cid_25161904

Type

Small organic molecule

Emp. Form.

C23H28N4O2S2

Mol. Mass.

456.624

SMILES

CN(C)C(CNC(=O)CSc1nc2sc3CCCCc3c2c(=O)n1C)c1ccccc1

Structure