| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil collagenase |
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| Ligand | BDBM50239951 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1667605 (CHEMBL4017401) |
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| IC50 | >5000±n/a nM |
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| Citation |  Choi, JY; Fuerst, R; Knapinska, AM; Taylor, AB; Smith, L; Cao, X; Hart, PJ; Fields, GB; Roush, WR Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors. J Med Chem60:5816-5825 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil collagenase |
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| Name: | Neutrophil collagenase |
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| Synonyms: | CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL |
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| Type: | Enzyme |
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| Mol. Mass.: | 53413.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22894 |
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| Residue: | 467 |
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| Sequence: | MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
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| BDBM50239951 |
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| n/a |
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| Name | BDBM50239951 |
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| Synonyms: | CHEMBL4100008 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23N3O4S2 |
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| Mol. Mass. | 457.566 |
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| SMILES | OCCNS(=O)(=O)c1ccc(cc1)-c1ccc(CSc2nc3CCCc3c(=O)[nH]2)cc1 |
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| Structure | 
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