Reaction Details |
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Target | Fibroblast growth factor receptor 4 |
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Ligand | BDBM50240779 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1668740 (CHEMBL4018628) |
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IC50 | 7.4±n/a nM |
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Citation | Zhu, W; Chen, H; Wang, Y; Wang, J; Peng, X; Chen, X; Gao, Y; Li, C; He, Y; Ai, J; Geng, M; Zheng, M; Liu, H Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer. J Med Chem60:6018-6035 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Fibroblast growth factor receptor 4 |
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Name: | Fibroblast growth factor receptor 4 |
Synonyms: | CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF |
Type: | Protein |
Mol. Mass.: | 87957.45 |
Organism: | Homo sapiens (Human) |
Description: | P22455 |
Residue: | 802 |
Sequence: | MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA
ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS
LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP
TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD
VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP
YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA
AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL
ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ
VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC
TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM
QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA
LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG
LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS
VFSHDPLPLGSSSFPFGSGVQT
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BDBM50240779 |
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n/a |
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Name | BDBM50240779 |
Synonyms: | CHEMBL4067871 |
Type | Small organic molecule |
Emp. Form. | C28H22ClN3O2 |
Mol. Mass. | 467.946 |
SMILES | OC[C@H](Nc1cnc(-c2cc(Cl)ccc2O)c(c1)-c1ccc2cnccc2c1)c1ccccc1 |r| |
Structure |
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