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TargetMetabotropic glutamate receptor 7
LigandBDBM50244219
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1673216 (CHEMBL4023245)
IC50>12500±n/a nM
Citation Monn, JAHenry, SSMassey, SMClawson, DKChen, QDiseroad, BABhardwaj, RMAtwell, SLu, FWang, JRussell, MHeinz, BAWang, XSCarter, JHGetman, BGAdragni, KBroad, LMSanger, HEUrsu, DCatlow, JTSwanson, SJohnson, BGShaw, DBMcKinzie, DLHao, J Synthesis and Pharmacological Characterization of C4 J Med Chem61:2303-2328 (2018) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Metabotropic glutamate receptor 7
Name:Metabotropic glutamate receptor 7
Synonyms:GPRC1G | GRM7 | GRM7 protein | GRM7_HUMAN | MGLUR7 | Metabotropic glutamate receptor 7 | metabotropic glutamate 7
Type:Enzyme Catalytic Domain
Mol. Mass.:102262.98
Organism:Homo sapiens (Human)
Description:Q14831
Residue:915
Sequence:
MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAK
GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL
TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA
STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ
ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK
RADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR
NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAH
ALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIF
QYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP
CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAML
GIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRV
FLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW
FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGV
PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML
YMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS
PAAKKKYVSYNNLVI
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  Blast E-value cutoff:
BDBM50244219
n/a
NameBDBM50244219
Synonyms:CHEMBL4081453
TypeSmall organic molecule
Emp. Form.C16H18N2O6
Mol. Mass.334.3239
SMILES[H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)(C[C@@H]2NC(=O)c1cccc(OC)c1)C(O)=O |r|
Structure
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