Reaction Details |
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Target | Receptor-interacting serine/threonine-protein kinase 1 |
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Ligand | BDBM50244721 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1673973 (CHEMBL4024002) |
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Ki | 81±n/a nM |
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Citation | Yoshikawa, M; Saitoh, M; Katoh, T; Seki, T; Bigi, SV; Shimizu, Y; Ishii, T; Okai, T; Kuno, M; Hattori, H; Watanabe, E; Saikatendu, KS; Zou, H; Nakakariya, M; Tatamiya, T; Nakada, Y; Yogo, T Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. J Med Chem61:2384-2409 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Receptor-interacting serine/threonine-protein kinase 1 |
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Name: | Receptor-interacting serine/threonine-protein kinase 1 |
Synonyms: | Cell death protein RIP | RIP-1 | RIPK1_MOUSE | Receptor-interacting protein 1 | Receptor-interacting serine/threonine-protein kinase 1 | Rinp | Rinp | Rip | Ripk1 | Serine/threonine-protein kinase RIP |
Type: | PROTEIN |
Mol. Mass.: | 74852.62 |
Organism: | Mus musculus |
Description: | ChEMBL_116773 |
Residue: | 656 |
Sequence: | MQPDMSLDNIKMASSDLLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVL
LEEGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGRIIV
EAIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVS
STTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYENVICTEQFVI
CIKSGNRPNVEEILEYCPREIISLMERCWQAIPEDRPTFLGIEEEFRPFYLSHFEEYVEE
DVASLKKEYPDQSPVLQRMFSLQHDCVPLPPSRSNSEQPGSLHSSQGLQMGPVEESWFSS
SPEYPQDENDRSVQAKLQEEASYHAFGIFAEKQTKPQPRQNEAYNREEERKRRVSHDPFA
QQRARENIKSAGARGHSDPSTTSRGIAVQQLSWPATQTVWNNGLYNQHGFGTTGTGVWYP
PNLSQMYSTYKTPVPETNIPGSTPTMPYFSGPVADDLIKYTIFNSSGIQIGNHNYMDVGL
NSQPPNNTCKEESTSRHQAIFDNTTSLTDEHLNPIRENLGRQWKNCARKLGFTESQIDEI
DHDYERDGLKEKVYQMLQKWLMREGTKGATVGKLAQALHQCCRIDLLNHLIRASQS
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BDBM50244721 |
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n/a |
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Name | BDBM50244721 |
Synonyms: | CHEMBL4100398 |
Type | Small organic molecule |
Emp. Form. | C24H20ClN5O3 |
Mol. Mass. | 461.9 |
SMILES | CN1c2ccc(cc2OC[C@H](N2CCc3c(Cl)n(Cc4ccccc4)nc3C2=O)C1=O)C#N |r| |
Structure |
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