| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor ionotropic, kainate 3 |
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| Ligand | BDBM50246916 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1677206 (CHEMBL4027349) |
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| Ki | >100000±n/a nM |
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| Citation |  Gynther, M; Proietti Silvestri, I; Hansen, JC; Hansen, KB; Malm, T; Ishchenko, Y; Larsen, Y; Han, L; Kayser, S; Auriola, S; Petsalo, A; Nielsen, B; Pickering, DS; Bunch, L Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist. J Med Chem60:9885-9904 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate receptor ionotropic, kainate 3 |
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| Name: | Glutamate receptor ionotropic, kainate 3 |
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| Synonyms: | GRIK3_RAT | Glur7 | Glutamate receptor ionotropic kainate 3 | Glutamate receptor ionotropic, kainate | Grik3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 104080.46 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1447329 |
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| Residue: | 919 |
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| Sequence: | MTAPWRRLRSLVWEYWAGFLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAF
RFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNA
VQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQSLKWRSATVVYD
DSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQ
ILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNAHVSAIVEKWS
MERLQAAPRAESGLLDGVMMTDAALLYDAVHIVSVCYQRASQMTVNSLQCHRHKPWRFGG
RFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVA
KGRGPNVTDSLTNRSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFS
YEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGV
SILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG
SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF
LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVK
NNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKIT
IAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAV
GEFIYKLRKTAEREQRSFCSTVADEIRFSLTCQRRLKHKPQPPMMVKTDAVINMHTFNDR
RLPGKDSMSCSTSLAPVFP
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| BDBM50246916 |
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| n/a |
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| Name | BDBM50246916 |
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| Synonyms: | CHEMBL4102488 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H16ClNO4 |
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| Mol. Mass. | 285.723 |
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| SMILES | Cl.Cc1ccc(cc1C(O)=O)[C@H]1CCN[C@@H]1C(O)=O |r| |
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| Structure | 
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