| Reaction Details |
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 | Report a problem with these data |
| Target | NUAK family SNF1-like kinase 1 |
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| Ligand | BDBM50248946 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1679548 (CHEMBL4029825) |
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| Ki | 1.7±n/a nM |
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| Citation |  Edupuganti, R; Taliaferro, JM; Wang, Q; Xie, X; Cho, EJ; Vidhu, F; Ren, P; Anslyn, EV; Bartholomeusz, C; Dalby, KN Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. Bioorg Med Chem25:2609-2616 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NUAK family SNF1-like kinase 1 |
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| Name: | NUAK family SNF1-like kinase 1 |
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| Synonyms: | ARK5 | KIAA0537 | NUAK1 | NUAK1_HUMAN | OMPHK1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74326.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1451343 |
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| Residue: | 661 |
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| Sequence: | MEGAAAPVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQET
LGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYE
VFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLK
LENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALG
VLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPSDARGLIRWMLMVNPDRRATIEDI
ANHWWVNWGYKSSVCDCDALHDSESPLLARIIDWHHRSTGLQADTEAKMKGLAKPTTSEV
MLERQRSLKKSKKENDFAQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGV
VGPALPSTFKMEQDLCRTGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYS
SPERSESSELLDSNDVMGSSIPSPSPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPAL
VSPEMPTLESLSEPGVPAEGLSRSYSRPSSVISDDSVLSSDSFDLLDLQENRPARQRIRS
CVSAENFLQIQDFEGLQNRPRPQYLKRYRNRLADSSFSLLTDMDDVTQVYKQALEICSKL
N
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| BDBM50248946 |
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| n/a |
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| Name | BDBM50248946 |
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| Synonyms: | CHEMBL1908392 | US10981896, Compound 16 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H31N5O2 |
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| Mol. Mass. | 481.5887 |
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| SMILES | CN(C(=O)CN1CCN(C)CC1)c1ccc(N\C(=C2/C(=O)Nc3ccccc23)c2ccccc2)cc1 |
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| Structure | 
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