| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium/calmodulin-dependent protein kinase kinase 2 |
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| Ligand | BDBM50248938 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1679545 (CHEMBL4029822) |
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| Ki | 85±n/a nM |
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| Citation |  Edupuganti, R; Taliaferro, JM; Wang, Q; Xie, X; Cho, EJ; Vidhu, F; Ren, P; Anslyn, EV; Bartholomeusz, C; Dalby, KN Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. Bioorg Med Chem25:2609-2616 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcium/calmodulin-dependent protein kinase kinase 2 |
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| Name: | Calcium/calmodulin-dependent protein kinase kinase 2 |
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| Synonyms: | CAMKK2 | CAMKKB | Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKKB) | Calcium/calmodulin-dependent protein kinase kinase beta | KIAA0787 | KKCC2_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 64746.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_27437015 |
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| Residue: | 588 |
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| Sequence: | MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS
LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKEARQRRQP
PGHRPAPRGGGGSALVRGSPCVESCWAPAPGSPARMHPLRPEEAMEPE
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| BDBM50248938 |
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| n/a |
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| Name | BDBM50248938 |
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| Synonyms: | CHEMBL4089284 | US10981896, Compound 21 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H31N5O4 |
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| Mol. Mass. | 525.5982 |
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| SMILES | CN(C(=O)CN1CCN(C)CC1)c1ccc(N\C(=C2/C(=O)Nc3ccc(cc23)C(O)=O)c2ccccc2)cc1 |
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| Structure | 
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