| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2B6 |
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| Ligand | BDBM50250181 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1681250 |
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| IC50 | >20000±n/a nM |
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| Citation |  Dos Santos Fernandes, GF; de Souza, PC; Moreno-Viguri, E; Santivañez-Veliz, M; Paucar, R; Pérez-Silanes, S; Chegaev, K; Guglielmo, S; Lazzarato, L; Fruttero, R; Man Chin, C; da Silva, PB; Chorilli, M; Solcia, MC; Ribeiro, CM; Silva, CSP; Marino, LB; Bosquesi, PL; Hunt, DM; de Carvalho, LPS; de Souza Costa, CA; Cho, SH; Wang, Y; Franzblau, SG; Pavan, FR; Dos Santos, JL Design, Synthesis, and Characterization of N-Oxide-Containing Heterocycles with in Vivo Sterilizing Antitubercular Activity. J Med Chem60:8647-8660 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2B6 |
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| Name: | Cytochrome P450 2B6 |
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| Synonyms: | CP2B6_HUMAN | CYP2B6 | Cytochrome P450 2B6 (CYP2B6) |
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| Type: | Protein |
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| Mol. Mass.: | 56289.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P20813 |
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| Residue: | 491 |
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| Sequence: | MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE
KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR
WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC
SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE
INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT
ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS
DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL
KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI
PPTYQIRFLPR
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| BDBM50250181 |
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| n/a |
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| Name | BDBM50250181 |
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| Synonyms: | CHEMBL2338421 | N''-(5-Benzofuroxanylmethylidene)Isoniazide |
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| Type | Small organic molecule |
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| Emp. Form. | C13H9N5O3 |
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| Mol. Mass. | 283.2423 |
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| SMILES | [O-][n+]1onc2ccc(\C=N\NC(=O)c3ccncc3)cc12 |
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| Structure | 
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