| Reaction Details |
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 | Report a problem with these data |
| Target | Toll-like receptor 4 |
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| Ligand | BDBM50250424 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1681666 |
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| EC50 | >10000±n/a nM |
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| Citation |  Chan, M; Kakitsubata, Y; Hayashi, T; Ahmadi, A; Yao, S; Shukla, NM; Oyama, SY; Baba, A; Nguyen, B; Corr, M; Suda, Y; Carson, DA; Cottam, HB; Wakao, M Structure-Activity Relationship Studies of Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands. J Med Chem60:9142-9161 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Toll-like receptor 4 |
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| Name: | Toll-like receptor 4 |
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| Synonyms: | TLR4 | TLR4-MD2 | TLR4_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 95675.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1436169 |
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| Residue: | 839 |
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| Sequence: | MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELNFYKIPDNLPFSTKNLD
LSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALG
AFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHL
DLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSL
NVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDI
IDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS
NKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLG
LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG
NSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPY
KCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQL
LVEVERMECATPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLML
LAGCIKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAA
NIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLR
QQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI
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| BDBM50250424 |
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| n/a |
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| Name | BDBM50250424 |
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| Synonyms: | CHEMBL4087701 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H31N5O5S |
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| Mol. Mass. | 561.652 |
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| SMILES | Cn1c2ccc(NC(=O)CCC(O)=O)cc2c2nc(SCC(=O)NC3CCCCC3)n(-c3ccccc3)c(=O)c12 |
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| Structure | 
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