Reaction Details |
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Target | Retinoblastoma-associated protein |
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Ligand | BDBM50251761 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1684306 |
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IC50 | 15000±n/a nM |
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Citation | Kulkarni, MR; Mane, MS; Ghosh, U; Sharma, R; Lad, NP; Srivastava, A; Kulkarni-Almeida, A; Kharkar, PS; Khedkar, VM; Pandit, SS Discovery of tetrahydrocarbazoles as dual pERK and pRb inhibitors. Eur J Med Chem134:366-378 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Retinoblastoma-associated protein |
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Name: | Retinoblastoma-associated protein |
Synonyms: | RB1 | RB_HUMAN | Rb | pRb | pp110 | retinoblastoma |
Type: | Other Protein Type |
Mol. Mass.: | 106170.80 |
Organism: | Homo sapiens (Human) |
Description: | P06400 |
Residue: | 928 |
Sequence: | MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTAL
CQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGICIFIAAVDLDEMSFTFTEL
QKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSS
ISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYK
TAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFM
NSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKS
NLDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVK
DIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDN
IFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEG
NLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNH
TAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYL
RLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLK
FKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLS
PIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFG
TSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQK
LAEMTSTRTRMQKQKMNDSMDTSNKEEK
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BDBM50251761 |
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n/a |
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Name | BDBM50251761 |
Synonyms: | CHEMBL4071674 |
Type | Small organic molecule |
Emp. Form. | C18H25ClN2 |
Mol. Mass. | 304.858 |
SMILES | Cl.C1CCC(CC1)NC1CCCc2c1[nH]c1ccccc21 |
Structure |
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