| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoblastoma-associated protein |
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| Ligand | BDBM50251768 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1684306 (CHEMBL4034785) |
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| IC50 | 15000±n/a nM |
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| Citation |  Kulkarni, MR; Mane, MS; Ghosh, U; Sharma, R; Lad, NP; Srivastava, A; Kulkarni-Almeida, A; Kharkar, PS; Khedkar, VM; Pandit, SS Discovery of tetrahydrocarbazoles as dual pERK and pRb inhibitors. Eur J Med Chem134:366-378 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoblastoma-associated protein |
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| Name: | Retinoblastoma-associated protein |
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| Synonyms: | RB1 | RB_HUMAN | Rb | pRb | pp110 | retinoblastoma |
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| Type: | Other Protein Type |
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| Mol. Mass.: | 106170.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06400 |
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| Residue: | 928 |
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| Sequence: | MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTAL
CQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGICIFIAAVDLDEMSFTFTEL
QKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSS
ISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYK
TAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFM
NSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKS
NLDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVK
DIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDN
IFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEG
NLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNH
TAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYL
RLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLK
FKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLS
PIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFG
TSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQK
LAEMTSTRTRMQKQKMNDSMDTSNKEEK
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| BDBM50251768 |
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| n/a |
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| Name | BDBM50251768 |
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| Synonyms: | CHEMBL4065808 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H24N2 |
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| Mol. Mass. | 268.3966 |
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| SMILES | CC1CCC(C1)NC1CCCc2c1[nH]c1ccccc21 |
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| Structure | 
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