| Reaction Details |
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 | Report a problem with these data |
| Target | Megakaryocyte-associated tyrosine-protein kinase |
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| Ligand | BDBM50252338 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1684615 |
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| IC50 | 14700±n/a nM |
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| Citation |  Zhou, D; Springer, MZ; Xu, D; Liu, D; Hudmon, A; Macleod, KF; Meroueh, SO Small molecules inhibit STAT3 activation, autophagy, and cancer cell anchorage-independent growth. Bioorg Med Chem25:2995-3005 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Megakaryocyte-associated tyrosine-protein kinase |
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| Name: | Megakaryocyte-associated tyrosine-protein kinase |
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| Synonyms: | CTK | HYL | MATK | MATK_HUMAN | Tyrosine-protein kinase CTK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56488.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774344 |
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| Residue: | 507 |
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| Sequence: | MAGRGSLVSWRAFHGCDSAEELPRVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHT
RPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLM
PWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTI
DEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQ
IGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQGL
YIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILV
SEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSY
GRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLAR
ELRSAGAPASVSGQDADGSTSPRSQEP
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| BDBM50252338 |
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| n/a |
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| Name | BDBM50252338 |
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| Synonyms: | CHEMBL4090364 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H30Cl3N5 |
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| Mol. Mass. | 506.898 |
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| SMILES | CCN(CC)CCCC(C)Nc1nc(\C=C\c2c(Cl)cc(Cl)cc2Cl)nc2ccc(N)cc12 |
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| Structure | 
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