| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calpain-1 catalytic subunit |
|---|
| Ligand | BDBM50258394 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1690433 |
|---|
| Ki | 20±n/a nM |
|---|
| Citation |  Kling, A; Jantos, K; Mack, H; Hornberger, W; Drescher, K; Nimmrich, V; Relo, A; Wicke, K; Hutchins, CW; Lao, Y; Marsh, K; Moeller, A Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides. J Med Chem60:7123-7138 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calpain-1 catalytic subunit |
|---|
| Name: | Calpain-1 catalytic subunit |
|---|
| Synonyms: | CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 81880.51 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 714 |
|---|
| Sequence: | MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA
FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK
ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE
VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV
LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
|
|
|
|---|
| BDBM50258394 |
|---|
| n/a |
|---|
| Name | BDBM50258394 |
|---|
| Synonyms: | CHEMBL4068214 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H23N5O3 |
|---|
| Mol. Mass. | 405.4497 |
|---|
| SMILES | CCCCC(NC(=O)c1cccnc1-n1cc(cn1)-c1ccccc1)C(=O)C(N)=O |
|---|
| Structure | 
|
|---|
Search and Browse
