| Reaction Details |
|---|
 | Report a problem with these data |
| Target | G-protein coupled receptor 4 |
|---|
| Ligand | BDBM50260330 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1693532 |
|---|
| IC50 | 1260±n/a nM |
|---|
| Citation |  Miltz, W; Velcicky, J; Dawson, J; Littlewood-Evans, A; Ludwig, MG; Seuwen, K; Feifel, R; Oberhauser, B; Meyer, A; Gabriel, D; Nash, M; Loetscher, P Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis. Bioorg Med Chem25:4512-4525 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| G-protein coupled receptor 4 |
|---|
| Name: | G-protein coupled receptor 4 |
|---|
| Synonyms: | G-protein coupled receptor 4 | GPR4_RAT | Gpr4 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 41280.26 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_117555 |
|---|
| Residue: | 365 |
|---|
| Sequence: | MDNSTGTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVRQRNELGVYLMN
LSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYSNIYISIAFLCCISVDRYLA
VAHPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMERWV
AWMNLYRVFVGFLFPWALMLLCYRGILRAVQSSVSTERQEKVKIKRLALSLIAIVLVCFA
PYHALLLSRSAVYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVA
KALHNLLRFLASNKPQEMANASLTLETPLTSKRSTTGKTSGAVWAVPPTAQGDQVPLKVL
LPPAQ
|
|
|
|---|
| BDBM50260330 |
|---|
| n/a |
|---|
| Name | BDBM50260330 |
|---|
| Synonyms: | CHEMBL4059983 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H39N5O |
|---|
| Mol. Mass. | 425.6101 |
|---|
| SMILES | CN(C)CCCCNC(=O)c1ccc(CN(CC(C)(C)C)c2cc(C)nc(C)n2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
