| Reaction Details |
|---|
 | Report a problem with these data |
| Target | G-protein coupled receptor 4 |
|---|
| Ligand | BDBM50260332 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1693561 |
|---|
| IC50 | 7310±n/a nM |
|---|
| Citation |  Miltz, W; Velcicky, J; Dawson, J; Littlewood-Evans, A; Ludwig, MG; Seuwen, K; Feifel, R; Oberhauser, B; Meyer, A; Gabriel, D; Nash, M; Loetscher, P Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis. Bioorg Med Chem25:4512-4525 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| G-protein coupled receptor 4 |
|---|
| Name: | G-protein coupled receptor 4 |
|---|
| Synonyms: | G-protein coupled receptor 4 | G-protein coupled receptor 4 (GPR4) | GPR4 | GPR4_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 40994.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P46093 |
|---|
| Residue: | 362 |
|---|
| Sequence: | MGNHTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLS
IADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVA
HPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMEGWVAW
MNLYRVFVGFLFPWALMLLSYRGILRAVRGSVSTERQEKAKIKRLALSLIAIVLVCFAPY
HVLLLSRSAIYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKA
LHNLLRFLASDKPQEMANASLTLETPLTSKRNSTAKAMTGSWAATPPSQGDQVQLKMLPP
AQ
|
|
|
|---|
| BDBM50260332 |
|---|
| n/a |
|---|
| Name | BDBM50260332 |
|---|
| Synonyms: | CHEMBL4095465 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H41N5 |
|---|
| Mol. Mass. | 459.6693 |
|---|
| SMILES | CC(C)Cc1nc2c(C)cc(C)nc2n1Cc1ccc(\C=C\CN2CCN(CC2)C(C)C)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
