| Reaction Details |
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 | Report a problem with these data |
| Target | Myeloblastin |
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| Ligand | BDBM50263166 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1697682 |
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| Ki | 5.4±n/a nM |
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| Citation |  Guarino, C; Gruba, N; Grzywa, R; Dyguda-Kazimierowicz, E; Hamon, Y; ??gowska, M; Skore?ski, M; Dallet-Choisy, S; Marchand-Adam, S; Kellenberger, C; Jenne, DE; Sie?czyk, M; Lesner, A; Gauthier, F; Korkmaz, B Exploiting the S4-S5 Specificity of Human Neutrophil Proteinase 3 to Improve the Potency of Peptidyl Di(chlorophenyl)-phosphonate Ester Inhibitors: A Kinetic and Molecular Modeling Analysis. J Med Chem61:1858-1870 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Myeloblastin |
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| Name: | Myeloblastin |
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| Synonyms: | Leukocyte proteinase 3 | MBN | PRTN3 | PRTN3_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 27816.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1463425 |
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| Residue: | 256 |
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| Sequence: | MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTL
IHPSFVLTAAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDVL
LIQLSSPANLSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVVTF
FCRPHNICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFPDFFTRVALYV
DWIRSTLRRVEAKGRP
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| BDBM50263166 |
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| n/a |
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| Name | BDBM50263166 |
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| Synonyms: | CHEMBL4071346 |
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| Type | Small organic molecule |
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| Emp. Form. | C44H55Cl2N6O11PS |
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| Mol. Mass. | 977.886 |
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| SMILES | [H][C@]12CS[C@@H](CCCCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CC(O)=O)C(=O)NC(CCC)P(=O)(Oc3ccc(Cl)cc3)Oc3ccc(Cl)cc3)[C@@]1([H])NC(=O)N2 |r| |
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| Structure | 
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