| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteine protease |
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| Ligand | BDBM50269331 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1705909 (CHEMBL4057142) |
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| IC50 | 18100±n/a nM |
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| Citation |  Schmidt, I; Göllner, S; Fuß, A; Stich, A; Kucharski, A; Schirmeister, T; Katzowitsch, E; Bruhn, H; Miliu, A; Krauth-Siegel, RL; Holzgrabe, U Bistacrines as potential antitrypanosomal agents. Bioorg Med Chem25:4526-4531 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteine protease |
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| Name: | Cysteine protease |
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| Synonyms: | Rhodesain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48425.78 |
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| Organism: | Trypanosoma brucei rhodesiense |
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| Description: | ChEMBL_619861 |
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| Residue: | 450 |
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| Sequence: | MPRTEMVRFVRLPVVLLAMAACLASVALGSLHVEESLEMRFAAFKKKYGKVYKDAKEEAF
RFRAFEENMEQAKIQAAANPYATFGVTPFSDMTREEFRARYRNGASYFAAAQKRLRKTVN
VTTGRAPAAVDWREKGAVTPVKDQGQCGSCWAFSTIGNIEGQWQVAGNPLVSLSEQMLVS
CDTIDFGCGGGLMDNAFNWIVNSNGGNVFTEASYPYVSGNGEQPQCQMNGHEIGAAITDH
VDLPQDEDAIAAYLAENGPLAIAVDATSFMDYNGGILTSCTSEQLDHGVLLVGYNDSSNP
PYWIIKNSWSNMWGEDGYIRIEKGTNQCLMNQAVSSAVVGGPTPPPPPPPPPSATFTQDF
CEGKGCTKGCSHATFPTGECVQTTGVGSVIATCGASNLTQIIYPLSRSCSGLSVPITVPL
DKCIPILIGSVEYHCSTNPPTKAARLVPHQ
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| BDBM50269331 |
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| n/a |
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| Name | BDBM50269331 |
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| Synonyms: | CHEMBL3815015 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H48N4O2 |
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| Mol. Mass. | 580.8026 |
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| SMILES | COc1ccc2nc3CCCCc3c(NCCCCCCCCCNc3c4CCCCc4nc4ccc(OC)cc34)c2c1 |
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| Structure | 
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