| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 1A1 |
|---|
| Ligand | BDBM55663 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1706501 (CHEMBL4057734) |
|---|
| IC50 | 5800±n/a nM |
|---|
| Citation |  Williams, IS; Joshi, P; Gatchie, L; Sharma, M; Satti, NK; Vishwakarma, RA; Chaudhuri, B; Bharate, SB Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance. Bioorg Med Chem Lett27:3683-3687 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 1A1 |
|---|
| Name: | Cytochrome P450 1A1 |
|---|
| Synonyms: | CP1A1_HUMAN | CYP1A1 | CYPIA1 | Cytochrome P450 1A | Cytochrome P450 1A1 | Cytochrome P450 1A1 (CYP1A1) | P450 form 6 | P450-C | P450-P1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 58177.23 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P04798 |
|---|
| Residue: | 512 |
|---|
| Sequence: | MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH
LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS
MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG
PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL
RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV
QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS
DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL
WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF
SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
|
|
|
|---|
| BDBM55663 |
|---|
| n/a |
|---|
| Name | BDBM55663 |
|---|
| Synonyms: | (E)-3-(1,3-benzodioxol-5-yl)-1-(1H-pyrrol-2-yl)-2-propen-1-one | (E)-3-(1,3-benzodioxol-5-yl)-1-(1H-pyrrol-2-yl)prop-2-en-1-one | MLS000698223 | SMR000227914 | cid_5787676 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H11NO3 |
|---|
| Mol. Mass. | 241.242 |
|---|
| SMILES | O=C(\C=C\c1ccc2OCOc2c1)c1ccc[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
