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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glutamate receptor ionotropic, NMDA 2B | ||
| Ligand | BDBM50269762 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_1707178 | ||
| IC50 | 158±n/a nM | ||
| Citation |  Anan, K; Masui, M; Hara, S; Ohara, M; Kume, M; Yamamoto, S; Shinohara, S; Tsuji, H; Shimada, S; Yagi, S; Hasebe, N; Kai, H Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach. Bioorg Med Chem Lett27:4194-4198 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glutamate receptor ionotropic, NMDA 2B | |||
| Name: | Glutamate receptor ionotropic, NMDA 2B | ||
| Synonyms: | GluN2B | Glutamate [NMDA] receptor subunit epsilon-2 | Glutamate receptor ionotropic, NMDA 2B | Grin2b | Ionotropic glutamate receptor NMDA1/2B | N-methyl D-aspartate receptor subtype 2B | NMDAR2B | NMDE2_MOUSE | NR2B | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 165965.49 | ||
| Organism: | Mus musculus | ||
| Description: | ChEMBL_117725 | ||
| Residue: | 1482 | ||
| Sequence: |
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| BDBM50269762 | |||
| n/a | |||
| Name | BDBM50269762 | ||
| Synonyms: | CHEMBL4063195 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H22ClN3O3 | ||
| Mol. Mass. | 399.871 | ||
| SMILES | O[C@]1(Cc2noc(n2)-c2ccc(=O)[nH]c2)CC[C@H](Cc2ccc(Cl)cc2)CC1 |r,wD:1.0,17.19,(13.85,-7.13,;14.62,-8.46,;13.08,-8.46,;12.31,-9.8,;12.94,-11.2,;11.79,-12.23,;10.46,-11.46,;10.78,-9.95,;9.05,-12.09,;7.81,-11.18,;6.41,-11.8,;6.24,-13.33,;4.83,-13.95,;7.49,-14.24,;8.9,-13.62,;15.95,-7.68,;17.28,-8.46,;17.28,-10,;18.61,-10.77,;19.95,-10.01,;21.28,-10.78,;22.61,-10.01,;22.61,-8.47,;23.95,-7.7,;21.27,-7.7,;19.94,-8.47,;15.95,-10.76,;14.62,-10,)| | ||
| Structure | 
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