Ki Summary

Reaction Details

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Target

Cysteinyl leukotriene receptor 1

Ligand

BDBM50006806

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_52211 (CHEMBL666680)

35±n/a nM

Citation

Huang, FC; Galemmo, RA; Johnson, WH; Poli, GB; Morrissette, MM; Mencel, JJ; Warus, JD; Campbell, HF; Nuss, GW; Carnathan, GW Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene D4 receptor antagonists. 2. Effects of an additional phenyl ring on receptor affinity. J Med Chem33:1194-200 (1990) [PubMed]

More Info.:

Get all data from this article, Assay Method

Cysteinyl leukotriene receptor 1

Name:

Cysteinyl leukotriene receptor 1

Synonyms:

CLTR1_CAVPO | CYSLTR1

Type:

Enzyme Catalytic Domain

Mol. Mass.:

39007.58

Organism:

GUINEA PIG

Description:

Leukotriene D4 0 GUINEA PIG::Q2NNR5

Residue:

340

Sequence:

MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSA
FQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAM
SFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPP
QDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIV
VTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFF
SGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE

BDBM50006806

n/a

Name

BDBM50006806

Synonyms:

C,C,C-Trifluoro-N-[3-(quinolin-2-ylmethoxy)-phenyl]-methanesulfonamide | C,C,C-Trifluoro-N-[3-(quinolin-2-ylmethoxy)-phenyl]-methanesulfonamide( Wy-48,252) | C,C,C-Trifluoro-N-[3-(quinolin-2-ylmethoxy)-phenyl]-methanesulfonamide(Wy 48252) | C,C,C-Trifluoro-N-[3-(quinolin-2-ylmethoxy)-phenyl]-methanesulfonamide(Wy-48,252) | CHEMBL17344 | Ritolukast

Type

Small organic molecule

Emp. Form.

C17H13F3N2O3S

Mol. Mass.

382.357

SMILES

FC(F)(F)S(=O)(=O)Nc1cccc(OCc2ccc3ccccc3n2)c1

Structure