Reaction Details |
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Target | Cysteinyl leukotriene receptor 1/2 |
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Ligand | BDBM50013534 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_52221 (CHEMBL663971) |
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Ki | 42±n/a nM |
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Citation | Galemmo, RA; Johnson, WH; Learn, KS; Lee, TD; Huang, FC; Campbell, HF; Youssefyeh, R; O'Rourke, SV; Schuessler, G; Sweeney, DM The development of a novel series of (quinolin-2-ylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 3. Structural variation of the acidic side chain to give antagonists of enhanced potency. J Med Chem33:2828-41 (1990) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Cysteinyl leukotriene receptor 1/2 |
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Name: | Cysteinyl leukotriene receptor 1/2 |
Synonyms: | Cysteinyl leukotriene receptor |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 98640 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Cysteinyl leukotriene receptor 1 |
Synonyms: | CLTR1_HUMAN | CYSLT1 | CYSLTR1 | Cysteinyl leukotriene D4 receptor | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 1 | HG55 | HMTMF81 | LTD4 receptor | Leukotriene Cysteinyl 1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 38565.16 |
Organism: | Homo sapiens (Human) |
Description: | Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271 |
Residue: | 337 |
Sequence: | MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQV
YMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFF
RCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDN
QTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTA
AFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGG
NFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
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Component 2 |
Name: | Cysteinyl leukotriene receptor 2 |
Synonyms: | CLTR2_HUMAN | CYSLT2 | CYSLT2R | CYSLTR2 | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 2 | Leukotriene Cysteinyl 2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 39657.52 |
Organism: | Homo sapiens (Human) |
Description: | Leukotriene Cysteinyl 2 CYSLTR2 HUMAN::Q9NS75 |
Residue: | 346 |
Sequence: | MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSI
YVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYV
NMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQ
NGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRV
SHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACF
NPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
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BDBM50013534 |
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n/a |
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Name | BDBM50013534 |
Synonyms: | 2-{3-[3-(1H-Tetrazol-5-yl)-propoxy]-phenoxymethyl}-quinoline | 2-{3-[3-(1H-Tetrazol-5-yl)-propoxy]-phenoxymethyl}-quinoline (RG 7152) | CHEMBL418551 |
Type | Small organic molecule |
Emp. Form. | C20H19N5O2 |
Mol. Mass. | 361.3972 |
SMILES | C(COc1cccc(OCc2ccc3ccccc3n2)c1)Cc1nnn[nH]1 |
Structure |
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