Reaction Details |
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Target | Serine/threonine-protein kinase PknA |
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Ligand | BDBM50279736 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1721604 (CHEMBL4136604) |
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Ki | 1800±n/a nM |
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Citation | Wang, T; Bemis, G; Hanzelka, B; Zuccola, H; Wynn, M; Moody, CS; Green, J; Locher, C; Liu, A; Gao, H; Xu, Y; Wang, S; Wang, J; Bennani, YL; Thomson, JA; Müh, U Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions. ACS Med Chem Lett8:1224-1229 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase PknA |
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Name: | Serine/threonine-protein kinase PknA |
Synonyms: | 2.7.11.1 | PKNA_MYCTU | Serine/threonine-protein kinase PknA | pknA |
Type: | PROTEIN |
Mol. Mass.: | 45619.67 |
Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Description: | ChEMBL_117830 |
Residue: | 431 |
Sequence: | MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRA
EARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALD
MLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGT
AQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPD
LPPNVRELIEITLVKNPAMRYRSGGPFADAVAAVRAGRRPPRPSQTPPPGRAAPAAIPSG
TTARVAANSAGRTAASRRSRPATGGHRPPRRTFSSGQRALLWAAGVLGALAIIIAVLLVI
KAPGDNSPQQAPTPTVTTTGNPPASNTGGTDASPRLNWTERGETRHSGLQSWVVPPTPHS
RASLARYEIAQ
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BDBM50279736 |
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n/a |
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Name | BDBM50279736 |
Synonyms: | CHEMBL4162511 |
Type | Small organic molecule |
Emp. Form. | C22H19ClN6O |
Mol. Mass. | 418.879 |
SMILES | NC(=O)Cc1ccc(cc1)-c1nc(Nc2cc([nH]n2)C2CC2)c2cc(Cl)ccc2n1 |
Structure |
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