| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PknA |
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| Ligand | BDBM50279757 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1721604 (CHEMBL4136604) |
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| Ki | <8.0±n/a nM |
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| Citation |  Wang, T; Bemis, G; Hanzelka, B; Zuccola, H; Wynn, M; Moody, CS; Green, J; Locher, C; Liu, A; Gao, H; Xu, Y; Wang, S; Wang, J; Bennani, YL; Thomson, JA; Müh, U Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions. ACS Med Chem Lett8:1224-1229 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PknA |
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| Name: | Serine/threonine-protein kinase PknA |
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| Synonyms: | 2.7.11.1 | PKNA_MYCTU | Serine/threonine-protein kinase PknA | pknA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45619.67 |
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| Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
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| Description: | ChEMBL_117830 |
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| Residue: | 431 |
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| Sequence: | MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRA
EARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALD
MLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGT
AQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPD
LPPNVRELIEITLVKNPAMRYRSGGPFADAVAAVRAGRRPPRPSQTPPPGRAAPAAIPSG
TTARVAANSAGRTAASRRSRPATGGHRPPRRTFSSGQRALLWAAGVLGALAIIIAVLLVI
KAPGDNSPQQAPTPTVTTTGNPPASNTGGTDASPRLNWTERGETRHSGLQSWVVPPTPHS
RASLARYEIAQ
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| BDBM50279757 |
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| n/a |
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| Name | BDBM50279757 |
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| Synonyms: | CHEMBL4166160 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15ClN6O2S2 |
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| Mol. Mass. | 446.934 |
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| SMILES | NS(=O)(=O)c1ccc(s1)-c1nc(Nc2cc([nH]n2)C2CC2)c2cc(Cl)ccc2n1 |
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| Structure | 
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