Reaction Details |
| Report a problem with these data |
Target | Bifunctional glucose-6-phosphate 1-dehydrogenase/6-phosphogluconolactonase |
---|
Ligand | BDBM50292585 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1731847 (CHEMBL4147383) |
---|
Ki | 34400±n/a nM |
---|
Citation | Alencar, N; Sola, I; Linares, M; Juárez-Jiménez, J; Pont, C; Viayna, A; Vílchez, D; Sampedro, C; Abad, P; Pérez-Benavente, S; Lameira, J; Bautista, JM; Muñoz-Torrero, D; Luque, FJ First homology model of Plasmodium falciparum glucose-6-phosphate dehydrogenase: Discovery of selective substrate analog-based inhibitors as novel antimalarial agents. Eur J Med Chem146:108-122 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Bifunctional glucose-6-phosphate 1-dehydrogenase/6-phosphogluconolactonase |
---|
Name: | Bifunctional glucose-6-phosphate 1-dehydrogenase/6-phosphogluconolactonase |
Synonyms: | 6-phosphogluconolactonase | 6PGL | G6PD | GLUPH_PLAF7 | GluPho | Glucose-6-phosphate 1-dehydrogenase | PfGluPho |
Type: | PROTEIN |
Mol. Mass.: | 106988.99 |
Organism: | Plasmodium falciparum (isolate 3D7) |
Description: | ChEMBL_117865 |
Residue: | 910 |
Sequence: | MDYENFVKSAEEINNLHNVNYLETKDLNDFNWKAAYYICKEIYDKQQINKDGYVVIGLSG
GRTPIDVYKNMCLIKDIKIDKSKLIFFIIDERYKSDDHKFSNYNNIKFLFHNLNINEKEQ
LYKPDTTKSIVDCILDYNDKIKIMIEKYKKVDIAILGMGSDFHIASLFPNIFYNIYMNNY
QNNYIYNEKTLDFINNDQDNDNLKYLKEYVYFTTTNQFDVRKRITVSLNLLANASSKIFL
LNSKDKLDLWKNMLIKSYIEVNYNLYPATYLIDTSCTNENVNINNNNNNNNKNKNNYCYS
NTTVISCGYENYTKSIEEIYDSKYALSLYSNSLNKEELLTIIIFGCSGDLAKKKIYPALF
KLFCNNSLPKDLLIIGFARTVQDFDTFFDKIVIYLKRCLLCYEDWSISKKKDLLNGFKNR
CRYFVGNYSSSESFENFNKYLTTIEEEEAKKKYYATCYKMNGSDYNISNNVAEDNISIDD
ENKTNEYFQMCTPKNCPDNVFSSNYNFPYVINRMLYLALPPHIFVSTLKNYKKNCLNSKG
TDKILLEKPFGNDLDSFKMLSKQILENFNEQQIYRIDHYLGKDMVSGLLKLKFTNTFLLS
LMNRHFIKCIKITLKETKGVYGRGQYFDPYGIIRDVMQNHMLQLLTLITMEDPIDLNDES
VKNEKIKILKSIPSIKLEDTIIGQYEKAENFKEDENNDDESKKNHSYHDDPHIDKNSITP
TFCTCILYINSINWYGVPIIFKSGKGLNKDICEIRIQFHNIMGSSDENMNNNEFVIILQP
VEAIYLKMMIKKTGCEEMEEVQLNLTVNEKNKKINVPEAYETLLLECFKGHKKKFISDEE
LYESWRIFTPLLKELQEKQVKPLKYSFGSSGPKEVFGLVKKYYNYGKNYTHRPEFVRKSS
FYEDDLLDIN
|
|
|
BDBM50292585 |
---|
n/a |
---|
Name | BDBM50292585 |
Synonyms: | CHEMBL4161382 |
Type | Small organic molecule |
Emp. Form. | C10H21NO7S |
Mol. Mass. | 299.341 |
SMILES | CO[C@H]1O[C@H](CS(=O)(=O)CCCN)[C@@H](O)[C@H](O)[C@H]1O |r| |
Structure |
|