| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
|---|
| Ligand | BDBM50315549 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1733219 (CHEMBL4148755) |
|---|
| Ki | 2250±n/a nM |
|---|
| Citation |  Abou Samra, A; Robert, A; Gov, C; Favre, L; Eloy, L; Jacquet, E; Bignon, J; Wiels, J; Desrat, S; Roussi, F Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A. Eur J Med Chem148:26-38 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
|---|
| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
|---|
| Synonyms: | Bcl-2-related protein EAT/mcl1 | MCL1_MOUSE | Mcl-1 | Mcl1 |
|---|
| Type: | Developmental protein |
|---|
| Mol. Mass.: | 35215.08 |
|---|
| Organism: | Mus musculus (Mouse) |
|---|
| Description: | n/a |
|---|
| Residue: | 331 |
|---|
| Sequence: | MFGLRRNAVIGLNLYCGGASLGAGGGSPAGARLVAEEAKARREGGGEAALLPGARVVARP
PPVGAEDPDVTASAERRLHKSPGLLAVPPEEMAASAAAAIVSPEEELDGCEPEAIGKRPA
VLPLLERVSEAAKSSGADGSLPSTPPPPEEEEDDLYRQSLEIISRYLREQATGSKDSKPL
GEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEGDVKSFSRVMVHVFKDGVT
NWGRIVTLISFGAFVAKHLKSVNQESFIEPLAETITDVLVRTKRDWLVKQRGWDGFVEFF
HVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR
|
|
|
|---|
| BDBM50315549 |
|---|
| n/a |
|---|
| Name | BDBM50315549 |
|---|
| Synonyms: | CHEMBL4175537 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H32ClN3O8 |
|---|
| Mol. Mass. | 586.033 |
|---|
| SMILES | [H][C@]12C[C@H](CCN=[N+]=[N-])C=C[C@]1([C@H](\C=C(/Cl)c1ccc(cc1)C(=O)OCOC(C)=O)C=C(C)C2)C(=O)OCOC(C)=O |r,c:9,t:32| |
|---|
| Structure | 
|
|---|
Search and Browse
