| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium-dependent phosphate transport protein 2A |
|---|
| Ligand | BDBM50327362 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1734226 (CHEMBL4149762) |
|---|
| Ki | 690±n/a nM |
|---|
| Citation |  Filipski, KJ; Sammons, MF; Bhattacharya, SK; Panteleev, J; Brown, JA; Loria, PM; Boehm, M; Smith, AC; Shavnya, A; Conn, EL; Song, K; Weng, Y; Facemire, C; Jüppner, H; Clerin, V Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). ACS Med Chem Lett9:440-445 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium-dependent phosphate transport protein 2A |
|---|
| Name: | Sodium-dependent phosphate transport protein 2A |
|---|
| Synonyms: | NPT2 | NPT2A_HUMAN | Na(+)-dependent phosphate cotransporter 2A | Na(+)/Pi cotransporter 2A | NaPi-2a | NaPi-3 | SLC17A2 | SLC34A1 | Sodium-dependent phosphate transport protein 2A | Sodium-phosphate transport protein 2A | Sodium/phosphate cotransporter 2A | Solute carrier family 34 member 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 68955.19 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_116742 |
|---|
| Residue: | 639 |
|---|
| Sequence: | MLSYGERLGSPAVSPLPVRGGHVMRGTAFAYVPSPQVLHRIPGTSAYAFPSLGPVALAEH
TCPCGEVLERHEPLPAKLALEEEQKPESRLVPKLRQAGAMLLKVPLMLTFLYLFVCSLDM
LSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLE
VSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAA
TGYLHHITRLVVASFNIHGGRDAPDLLKIITEPFTKLIIQLDESVITSIATGDESLRNHS
LIQIWCHPDSLQAPTSMSRAEANSSQTLGNATMEKCNHIFVDTGLPDLAVGLILLAGSLV
LLCTCLILLVKMLNSLLKGQVAKVIQKVINTDFPAPFTWVTGYFAMVVGASMTFVVQSSS
VFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSAFQIALCHFFF
NISGILLWYPVPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQV
MVGVGTPFGALLAFVVLINVLQSRSPGHLPKWLQTWDFLPRWMHSLKPLDHLITRATLCC
ARPEPRSPPLPPRVFLEELPPATPSPRLALPAHHNATRL
|
|
|
|---|
| BDBM50327362 |
|---|
| n/a |
|---|
| Name | BDBM50327362 |
|---|
| Synonyms: | CHEMBL4159390 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H23ClFN3O4S |
|---|
| Mol. Mass. | 515.984 |
|---|
| SMILES | OCC(O)CSCc1cccc(c1)C(=O)Nc1ccc(Cl)cc1C(=O)N\N=C\c1cccc(F)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
