| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent phosphate transporter 2 |
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| Ligand | BDBM50327359 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1734219 (CHEMBL4149755) |
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| IC50 | >25000±n/a nM |
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| Citation |  Filipski, KJ; Sammons, MF; Bhattacharya, SK; Panteleev, J; Brown, JA; Loria, PM; Boehm, M; Smith, AC; Shavnya, A; Conn, EL; Song, K; Weng, Y; Facemire, C; Jüppner, H; Clerin, V Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). ACS Med Chem Lett9:440-445 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent phosphate transporter 2 |
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| Name: | Sodium-dependent phosphate transporter 2 |
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| Synonyms: | GLVR-2 | GLVR2 | Gibbon ape leukemia virus receptor 2 | PIT2 | Phosphate transporter 2 | PiT-2 | S20A2_HUMAN | SLC20A2 | Sodium-dependent phosphate transporter 2 | Solute carrier family 20 member 2 | hPit2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 70391.57 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118051 |
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| Residue: | 652 |
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| Sequence: | MAMDEYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSV
LLGAKVGETIRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVG
STIGFSLVAIGTKGVQWMELVKIVASWFISPLLSGFMSGLLFVLIRIFILKKEDPVPNGL
RALPVFYAATIAINVFSIMYTGAPVLGLVLPMWAIALISFGVALLFAFFVWLFVCPWMRR
KITGKLQKEGALSRVSDESLSKVQEAESPVFKELPGAKANDDSTIPLTGAAGETLGTSEG
TSAGSHPRAAYGRALSMTHGSVKSPISNGTFGFDGHTRSDGHVYHTVHKDSGLYKDLLHK
IHIDRGPEEKPAQESNYRLLRRNNSYTCYTAAICGLPVHATFRAADSSAPEDSEKLVGDT
VSYSKKRLRYDSYSSYCNAVAEAEIEAEEGGVEMKLASELADPDQPREDPAEEEKEEKDA
PEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYKQGGVTQEAATPVWLLFYG
GVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVG
SVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAVMALLMYGILPYV
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| BDBM50327359 |
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| n/a |
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| Name | BDBM50327359 |
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| Synonyms: | CHEMBL4160507 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15ClF3N5 |
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| Mol. Mass. | 357.761 |
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| SMILES | Cc1[nH]c2c(N3CCC(N)CC3)c(C#N)c(nc2c1Cl)C(F)(F)F |
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| Structure | 
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