Reaction Details |
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Target | Sodium-dependent phosphate transport protein 2A |
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Ligand | BDBM50341383 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1734228 (CHEMBL4149764) |
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IC50 | 400±n/a nM |
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Citation | Filipski, KJ; Sammons, MF; Bhattacharya, SK; Panteleev, J; Brown, JA; Loria, PM; Boehm, M; Smith, AC; Shavnya, A; Conn, EL; Song, K; Weng, Y; Facemire, C; Jüppner, H; Clerin, V Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). ACS Med Chem Lett9:440-445 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent phosphate transport protein 2A |
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Name: | Sodium-dependent phosphate transport protein 2A |
Synonyms: | NPT2A_RAT | Na(+)-dependent phosphate cotransporter 2A | Na(+)/Pi cotransporter 2A | NaPi-2a | Slc17a2 | Slc34a1 | Sodium-dependent phosphate transport protein 2A | Sodium-phosphate transport protein 2A | Sodium/phosphate cotransporter 2A | Solute carrier family 34 member 1 |
Type: | PROTEIN |
Mol. Mass.: | 68723.74 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_118269 |
Residue: | 637 |
Sequence: | MMSYSERLGGPAVSPLPVRGRHMVHGAAFAYVPSPQVLHRIPGTTTYAISSLSPVALTEH
SCPYGEVLECHDPLPAKLAQEEEQKPEPRLSQKLAQVGTKLLKVPLMLGFLYLFVCSLDV
LSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLE
VSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAA
TGYLHHVTGLVVASFNIRGGRDAPDLLKVITEPFTKLIIQLDKSVITSIAVGDESLRNHS
LIRIWCQPETKEASTSMSRVEAIGSLANTTMEKCNHIFVDTGLPDLAVGLILLAGSLVVL
CTCLILLVKMLNSLLKGQVANVIQKVINTDFPAPFTWVTGYFAMVVGASMTFVVQSSSVF
TSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSSFQIALCHFFFNI
SGILLWYPLPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQAMV
GVGTPFGALLAFVVLVNVLQSRSPGHLPKWLQTWDFLPRWMHSLQPLDGLITRATLCYAR
PEPRSPQLPPRVFLEELPPATPSPRLALPAHHNATRL
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BDBM50341383 |
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n/a |
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Name | BDBM50341383 |
Synonyms: | CHEMBL4175607 |
Type | Small organic molecule |
Emp. Form. | C15H14ClF3N4O2 |
Mol. Mass. | 374.745 |
SMILES | Cc1[nH]c2c(N3CCO[C@H](CO)C3)c(C#N)c(nc2c1Cl)C(F)(F)F |r| |
Structure |
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