Reaction Details |
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Target | Group 10 secretory phospholipase A2 |
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Ligand | BDBM50366876 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1735577 (CHEMBL4151113) |
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IC50 | 230±n/a nM |
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Citation | Knerr, L; Giordanetto, F; Nordberg, P; Pettersen, D; Selmi, N; Beisel, HG; de la Motte, H; Olsson, T; Perkins, TDJ; Herslöf, M; Månsson, Å; Dahlström, M; Starke, I; Broddefalk, J; Saarinen, G; Klingegård, F; Hurt-Camejo, E; Rosengren, B; Brengdahl, J; Jansen, F; Rohman, M; Sandmark, J; Hallberg, K; Åkerud, T; Roth, RG; Ahlqvist, M Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A ACS Med Chem Lett9:594-599 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Group 10 secretory phospholipase A2 |
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Name: | Group 10 secretory phospholipase A2 |
Synonyms: | Group X secretory phospholipase A2 | PA2GX_HUMAN | PLA2G10 |
Type: | PROTEIN |
Mol. Mass.: | 18153.11 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1442449 |
Residue: | 165 |
Sequence: | MGPLPVCLPIMLLLLLPSLLLLLLLPGPGSGEASRILRVHRRGILELAGTVGCVGPRTPI
AYMKYGCFCGLGGHGQPRDAIDWCCHGHDCCYTRAEEAGCSPKTERYSWQCVNQSVLCGP
AENKCQELLCKCDQEIANCLAQTEYNLKYLFYPQFLCEPDSPKCD
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BDBM50366876 |
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n/a |
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Name | BDBM50366876 |
Synonyms: | CHEMBL4171797 |
Type | Small organic molecule |
Emp. Form. | C19H18N2O3 |
Mol. Mass. | 322.3578 |
SMILES | Cc1ccc2cc(C(N)=O)n(-c3cccc(CCC(O)=O)c3)c2c1 |
Structure |
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