| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Phospholipase A2 group V |
|---|
| Ligand | BDBM50055366 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1735581 (CHEMBL4151117) |
|---|
| IC50 | 124±n/a nM |
|---|
| Citation |  Knerr, L; Giordanetto, F; Nordberg, P; Pettersen, D; Selmi, N; Beisel, HG; de la Motte, H; Olsson, T; Perkins, TDJ; Herslöf, M; Månsson, Å; Dahlström, M; Starke, I; Broddefalk, J; Saarinen, G; Klingegård, F; Hurt-Camejo, E; Rosengren, B; Brengdahl, J; Jansen, F; Rohman, M; Sandmark, J; Hallberg, K; Åkerud, T; Roth, RG; Ahlqvist, M Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A ACS Med Chem Lett9:594-599 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Phospholipase A2 group V |
|---|
| Name: | Phospholipase A2 group V |
|---|
| Synonyms: | PA2G5_HUMAN | PLA2G5 | Phospholipase A2 group V | Secretory phospholipase A2, group V (sPLA2-V) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 15682.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 138 |
|---|
| Sequence: | MKGLLPLAWFLACSVPAVQGGLLDLKSMIEKVTGKNALTNYGFYGCYCGWGGRGTPKDGT
DWCCWAHDHCYGRLEEKGCNIRTQSYKYRFAWGVVTCEPGPFCHVNLCACDRKLVYCLKR
NLRSYNPQYQYFPNILCS
|
|
|
|---|
| BDBM50055366 |
|---|
| n/a |
|---|
| Name | BDBM50055366 |
|---|
| Synonyms: | (3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-acetic acid | (3-Aminooxalyl-1-benzyl-2-ethyl-2,3-dihydro-1H-indol-4-yloxy)-acetic acid | 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetic acid | CHEMBL148674 | Varespladib sodium |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H20N2O5 |
|---|
| Mol. Mass. | 380.3939 |
|---|
| SMILES | CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
