Reaction Details |
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Target | Lanosterol synthase |
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Ligand | BDBM50450466 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1742587 (CHEMBL4158337) |
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IC50 | <10000±n/a nM |
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Citation | Buchler, I; Akuma, D; Au, V; Carr, G; de León, P; DePasquale, M; Ernst, G; Huang, Y; Kimos, M; Kolobova, A; Poslusney, M; Wei, H; Swinnen, D; Montel, F; Moureau, F; Jigorel, E; Schulze, MED; Wood, M; Barrow, JC Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase. J Med Chem61:9647-9665 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lanosterol synthase |
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Name: | Lanosterol synthase |
Synonyms: | LSS_RAT | Lss | Osc |
Type: | PROTEIN |
Mol. Mass.: | 83302.12 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_12083 |
Residue: | 733 |
Sequence: | MTEGTCLRRRGGPYKTEPATDLTRWRLHNELGRQRWTYYQAEEDPGREQTGLEAHSLGLD
TTSYFKNLPKAQTAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPL
PAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALSYVSLRILGIGPDDPDLVRARNI
LHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQVYLP
MSYCYATRLSASEDPLVQSLRQELYVEDYASIDWPAQKNNVCPDDMYTPHSWLLHVVYGL
LNLYERFHSTSLRKWAIQLLYEHVAADDRFTKCISIGPISKTVNMLIRWSVDGPSSPAFQ
EHVSRIKDYLWLGLDGMKMQGTNGSQTWDTSFAVQALLEAGAHRRPEFLPCLQKAHEFLR
LSQVPDNNPDYQKYYRHMHKGGFPFSTLDCGWIVADCTAEALKAVLLLQERCPSITEHVP
RERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQ
ALRHFREYFPDHRATESRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACM
GHIYQNRTACAEVAQACHFLLSRQMADGGWGEDFESCEQRRYVQSAGSQVHSTCWALLGL
MAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTNYRNIFPIWALGRF
SSLYPDNTLAGHI
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BDBM50450466 |
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n/a |
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Name | BDBM50450466 |
Synonyms: | CHEMBL4165800 |
Type | Small organic molecule |
Emp. Form. | C17H12F3NO3S |
Mol. Mass. | 367.342 |
SMILES | Cc1ccc(cc1)S(=O)(=O)c1cc(c(O)c2ncccc12)C(F)(F)F |
Structure |
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