| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride lipase |
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| Ligand | BDBM50450707 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1743307 (CHEMBL4177817) |
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| IC50 | 3.8±n/a nM |
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| Citation |  Tuo, W; Leleu-Chavain, N; Spencer, J; Sansook, S; Millet, R; Chavatte, P Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors. J Med Chem60:4-46 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoglyceride lipase |
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| Name: | Monoglyceride lipase |
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| Synonyms: | MAG lipase | MGLL_MOUSE | Mgll | Monoacylglycerol lipase | Monoglyceride Lipase (MGL) |
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| Type: | Hydrolase |
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| Mol. Mass.: | 33391.67 |
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| Organism: | Mus musculus (mouse) |
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| Description: | Assays were using membranes of recombinant MAG Lipase transiently transfected in COS-7 cells. |
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| Residue: | 303 |
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| Sequence: | MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDE
LAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLG
HSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRID
SSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADR
LCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAG
CPP
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| BDBM50450707 |
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| n/a |
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| Name | BDBM50450707 |
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| Synonyms: | CHEMBL4215558 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17ClF6N2O4S |
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| Mol. Mass. | 482.826 |
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| SMILES | FC(F)(F)C(OC(=O)N1CCC(CNS(=O)(=O)c2ccc(Cl)cc2)CC1)C(F)(F)F |
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| Structure | 
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