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TargetNeuronal acetylcholine receptor subunit alpha-7
LigandBDBM50451615
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1745955 (CHEMBL4180465)
EC50 69±n/a nM
Citation Cook, J; Zusi, FC; Hill, MD; Fang, H; Pearce, B; Park, H; Gallagher, L; McDonald, IM; Bristow, L; Macor, JE; Olson, RE Design and synthesis of a novel series of (1'S,2R,4'S)-3H-4'-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2'-bicyclo[2.2.2]octanes] with high affinity for the ?7 neuronal nicotinic receptor. Bioorg Med Chem Lett27:5002-5005 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neuronal acetylcholine receptor subunit alpha-7
Name:Neuronal acetylcholine receptor subunit alpha-7
Synonyms:ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:Enzyme
Mol. Mass.:56502.44
Organism:Rattus norvegicus (Rat)
Description:Q05941
Residue:502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDL
QMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHK
PRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHL
MHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
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BDBM50451615
n/a
NameBDBM50451615
Synonyms:CHEMBL4203125
TypeSmall organic molecule
Emp. Form.C16H16F3N3O
Mol. Mass.323.3129
SMILESFC(F)(F)c1ccc2nc3O[C@@]4(Cn3c2c1)CN1CCC4CC1 |r,wU:11.10,THB:10:11:18.19:22.21,(23.72,-22.53,;22.33,-23.35,;23.73,-24.15,;21.92,-24.92,;21.18,-22.21,;21.57,-20.72,;20.47,-19.64,;18.99,-20.05,;17.7,-19.21,;16.51,-20.19,;14.98,-20.27,;14.59,-21.76,;15.87,-22.59,;17.07,-21.62,;18.6,-21.53,;19.7,-22.62,;14.89,-23.22,;13.45,-22.56,;11.84,-23.25,;11.62,-21.8,;13.17,-21.12,;13.24,-19.4,;13.72,-20.57,)|
Structure
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