Reaction Details | |||
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Target | 5-hydroxytryptamine receptor 3A | ||
Ligand | BDBM50451617 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1745956 (CHEMBL4180466) | ||
IC50 | 6.0±n/a nM | ||
Citation | Cook, J; Zusi, FC; Hill, MD; Fang, H; Pearce, B; Park, H; Gallagher, L; McDonald, IM; Bristow, L; Macor, JE; Olson, RE Design and synthesis of a novel series of (1'S,2R,4'S)-3H-4'-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2'-bicyclo[2.2.2]octanes] with high affinity for the ?7 neuronal nicotinic receptor. Bioorg Med Chem Lett27:5002-5005 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
5-hydroxytryptamine receptor 3A | |||
Name: | 5-hydroxytryptamine receptor 3A | ||
Synonyms: | 5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3 | ||
Type: | Protein | ||
Mol. Mass.: | 55283.27 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P46098 | ||
Residue: | 478 | ||
Sequence: |
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BDBM50451617 | |||
n/a | |||
Name | BDBM50451617 | ||
Synonyms: | CHEMBL4206339 | ||
Type | Small organic molecule | ||
Emp. Form. | C15H16ClN3O | ||
Mol. Mass. | 289.76 | ||
SMILES | Clc1ccc2n3C[C@@]4(CN5CCC4CC5)Oc3nc2c1 |r,wU:7.16,THB:15:7:10.11:14.13,(20.93,-19.2,;19.37,-19.62,;18.98,-21.11,;17.49,-21.52,;16.4,-20.43,;14.86,-20.52,;13.67,-21.49,;12.38,-20.66,;12.68,-22.12,;11.24,-21.46,;9.63,-22.15,;9.42,-20.69,;10.97,-20.02,;11.04,-18.3,;11.51,-19.47,;12.77,-19.17,;14.3,-19.09,;15.5,-18.11,;16.78,-18.95,;18.27,-18.54,)| | ||
Structure |