Reaction Details |
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Target | Alkaline phosphatase, tissue-nonspecific isozyme |
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Ligand | BDBM409779 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1751741 (CHEMBL4186501) |
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IC50 | 26±n/a nM |
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Citation | Pinkerton, AB; Sergienko, E; Bravo, Y; Dahl, R; Ma, CT; Sun, Q; Jackson, MR; Cosford, NDP; Millán, JL Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. Bioorg Med Chem Lett28:31-34 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Alkaline phosphatase, tissue-nonspecific isozyme |
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Name: | Alkaline phosphatase, tissue-nonspecific isozyme |
Synonyms: | ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor |
Type: | PROTEIN |
Mol. Mass.: | 57306.17 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1448917 |
Residue: | 524 |
Sequence: | MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
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BDBM409779 |
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n/a |
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Name | BDBM409779 |
Synonyms: | US10370333, Example II-2 |
Type | Small organic molecule |
Emp. Form. | C17H13F3N2O3S |
Mol. Mass. | 382.357 |
SMILES | COc1ccc(cc1S(=O)(=O)Nc1cnc2ccccc2c1)C(F)(F)F |
Structure |
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