Reaction Details |
| Report a problem with these data |
Target | Alkaline phosphatase, tissue-nonspecific isozyme |
---|
Ligand | BDBM46004 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1751741 (CHEMBL4186501) |
---|
IC50 | 6.0±n/a nM |
---|
Citation | Pinkerton, AB; Sergienko, E; Bravo, Y; Dahl, R; Ma, CT; Sun, Q; Jackson, MR; Cosford, NDP; Millán, JL Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. Bioorg Med Chem Lett28:31-34 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Alkaline phosphatase, tissue-nonspecific isozyme |
---|
Name: | Alkaline phosphatase, tissue-nonspecific isozyme |
Synonyms: | ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor |
Type: | PROTEIN |
Mol. Mass.: | 57306.17 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1448917 |
Residue: | 524 |
Sequence: | MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
|
|
|
BDBM46004 |
---|
n/a |
---|
Name | BDBM46004 |
Synonyms: | 5-chloranyl-2-methoxy-N-quinolin-3-yl-benzenesulfonamide | 5-chloro-2-methoxy-N-(3-quinolinyl)benzenesulfonamide | 5-chloro-2-methoxy-N-(3-quinolyl)benzenesulfonamide | 5-chloro-2-methoxy-N-quinolin-3-ylbenzenesulfonamide | MLS-0202007.0001 | US10370333, Example II-1 | cid_4679684 |
Type | Small organic molecule |
Emp. Form. | C16H13ClN2O3S |
Mol. Mass. | 348.804 |
SMILES | COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2ccccc2c1 |
Structure |
|