Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Cytochrome P450 3A4 |
---|
Ligand | BDBM50454640 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1752996 (CHEMBL4187756) |
---|
IC50 | >10000±n/a nM |
---|
Citation | Pieters, S; McGowan, D; Herschke, F; Pauwels, F; Stoops, B; Last, S; Embrechts, W; Scholliers, A; Mostmans, W; Van Dijck, K; Van Schoubroeck, B; Thoné, T; De Pooter, D; Fanning, G; Rosauro, ML; Khamlichi, MD; Houpis, I; Arnoult, E; Jonckers, THM; Raboisson, P Discovery of selective 2,4-diaminoquinazoline toll-like receptor 7 (TLR 7) agonists. Bioorg Med Chem Lett28:711-719 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cytochrome P450 3A4 |
---|
Name: | Cytochrome P450 3A4 |
Synonyms: | Albendazole monooxygenase | Albendazole sulfoxidase | CP3A4_HUMAN | CYP3A3 | CYP3A4 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 3A4 (CYP3A4) | Cytochrome P450 HLp | Nifedipine oxidase | Quinine 3-monooxygenase | Taurochenodeoxycholate 6-alpha-hydroxylase |
Type: | Enzyme |
Mol. Mass.: | 57349.57 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 503 |
Sequence: | MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
GLLQPEKPVVLKVESRDGTVSGA
|
|
|
BDBM50454640 |
---|
n/a |
---|
Name | BDBM50454640 |
Synonyms: | CHEMBL4218074 |
Type | Small organic molecule |
Emp. Form. | C18H21N5O |
Mol. Mass. | 323.3922 |
SMILES | CCCCNc1nc(N)nc2cccc(OCc3ccccn3)c12 |
Structure |
|