| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4 |
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| Ligand | BDBM50455054 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1753761 (CHEMBL4188521) |
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| IC50 | 9.7±n/a nM |
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| Citation |  Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Design and synthesis of 4-(2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)-N-(5-(piperazin-1-ylmethyl)pyridine-2-yl)pyrimidin-2-amine as a highly potent and selective cyclin-dependent kinases 4 and 6 inhibitors and the discovery of structure-activity relationships. Bioorg Med Chem Lett28:974-978 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 4 |
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| Name: | Cyclin-dependent kinase 4 |
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| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33731.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11802 |
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| Residue: | 303 |
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| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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| BDBM50455054 |
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| n/a |
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| Name | BDBM50455054 |
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| Synonyms: | CHEMBL4207451 | US10696678, Example 48 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H32F2N8 |
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| Mol. Mass. | 530.6148 |
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| SMILES | CC1(C)CCc2nc3c(F)cc(cc3n12)-c1nc(Nc2ccc(CN3CCN(CC3)C3CC3)cn2)ncc1F |
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| Structure | 
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