Reaction Details |
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Target | Cyclin-dependent kinase 6 |
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Ligand | BDBM50455058 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1753762 (CHEMBL4188522) |
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IC50 | 46±n/a nM |
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Citation | Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Design and synthesis of 4-(2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)-N-(5-(piperazin-1-ylmethyl)pyridine-2-yl)pyrimidin-2-amine as a highly potent and selective cyclin-dependent kinases 4 and 6 inhibitors and the discovery of structure-activity relationships. Bioorg Med Chem Lett28:974-978 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 6 |
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Name: | Cyclin-dependent kinase 6 |
Synonyms: | CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE |
Type: | Enzyme Subunit |
Mol. Mass.: | 36937.42 |
Organism: | Homo sapiens (Human) |
Description: | Q00534 |
Residue: | 326 |
Sequence: | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
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BDBM50455058 |
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n/a |
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Name | BDBM50455058 |
Synonyms: | CHEMBL4208366 | US10696678, Example 14 |
Type | Small organic molecule |
Emp. Form. | C27H30F2N8 |
Mol. Mass. | 504.5775 |
SMILES | CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CCCCn5c4c3)nc2)CC1 |
Structure |
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