Reaction Details |
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Target | Lanosterol synthase |
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Ligand | BDBM50456341 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1755336 (CHEMBL4190096) |
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IC50 | 120±n/a nM |
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Citation | Tani, O; Akutsu, Y; Ito, S; Suzuki, T; Tateishi, Y; Yamaguchi, T; Niimi, T; Namatame, I; Chiba, Y; Sakashita, H; Kubota, T; Yanagi, T; Mizukami, S; Hirayama, K; Furukawa, K; Yamasaki, K NMR Biochemical Assay for Oxidosqualene Cyclase: Evaluation of Inhibitor Activities on Trypanosoma cruzi and Human Enzymes. J Med Chem61:5047-5053 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lanosterol synthase |
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Name: | Lanosterol synthase |
Synonyms: | 2,3-epoxysqualene--lanosterol cyclase | LSS | LSS_HUMAN | OSC | Oxidosqualene--lanosterol cyclase |
Type: | PROTEIN |
Mol. Mass.: | 83309.32 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_11231 |
Residue: | 732 |
Sequence: | MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDT
KNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLP
AGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNIL
HKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM
SYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALL
NLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQE
HVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRL
SQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPR
ERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQA
LKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMG
QTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLM
AVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFS
QLYPERALAGHP
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BDBM50456341 |
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n/a |
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Name | BDBM50456341 |
Synonyms: | CHEMBL4212932 |
Type | Small organic molecule |
Emp. Form. | C21H28ClFN2O4S |
Mol. Mass. | 458.974 |
SMILES | Cl.CN(C)CCOc1ccc(OC2CCN(CC2)S(=O)(=O)c2ccc(F)cc2)cc1 |
Structure |
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