| Reaction Details |
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 | Report a problem with these data |
| Target | Prothrombin |
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| Ligand | BDBM50112073 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1761089 (CHEMBL4196336) |
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| IC50 | 32±n/a nM |
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| Citation |  Xie, Z; Tian, Y; Lv, X; Xiao, X; Zhan, M; Cheng, K; Li, S; Liao, C The selectivity and bioavailability improvement of novel oral anticoagulants: An overview. Eur J Med Chem146:299-317 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prothrombin |
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| Name: | Prothrombin |
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| Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
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| Type: | Protein |
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| Mol. Mass.: | 70029.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00734 |
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| Residue: | 622 |
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| Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
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| BDBM50112073 |
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| n/a |
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| Name | BDBM50112073 |
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| Synonyms: | CHEMBL417360 | [{2-[2-(4-Carbamimidoyl-phenyl)-ethyl]-1-methyl-1H-benzoimidazol-5-yl}-(quinoline-8-sulfonyl)-amino]-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C28H26N6O4S |
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| Mol. Mass. | 542.609 |
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| SMILES | Cn1c(CCc2ccc(cc2)C(N)=N)nc2cc(ccc12)N(CC(O)=O)S(=O)(=O)c1cccc2cccnc12 |
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| Structure | 
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