| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Epithelial discoidin domain-containing receptor 1 |
|---|
| Ligand | BDBM347342 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1764329 (CHEMBL4199576) |
|---|
| Kd | 40.0±n/a nM |
|---|
| Citation |  Schenck Eidam, H; Russell, J; Raha, K; DeMartino, M; Qin, D; Guan, HA; Zhang, Z; Zhen, G; Yu, H; Wu, C; Pan, Y; Joberty, G; Zinn, N; Laquerre, S; Robinson, S; White, A; Giddings, A; Mohammadi, E; Greenwood-Van Meerveld, B; Oliff, A; Kumar, S; Cheung, M Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS. ACS Med Chem Lett9:623-628 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Epithelial discoidin domain-containing receptor 1 |
|---|
| Name: | Epithelial discoidin domain-containing receptor 1 |
|---|
| Synonyms: | 2.7.10.1 | CD167 antigen-like family member A | CD_antigen=CD167a | Cell adhesion kinase | DDR1_RAT | Ddr1 | Discoidin receptor tyrosine kinase | Eddr1 | Epithelial discoidin domain receptor 1 | Epithelial discoidin domain-containing receptor 1 | Protein-tyrosine kinase 3 | Ptk3 | Tyrosine kinase DDR | Tyrosine-protein kinase CAK |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 101163.56 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_118104 |
|---|
| Residue: | 910 |
|---|
| Sequence: | MGTGTLSSLLLLLLLVTIGDADMKGHFDPAKCRYALGMQDRTIPDSDISVSSSWSDSTAA
RHSRLESSDGDGAWCPAGPVFPKEEEYLQVDLRRLHLVALVGTQGRHAGGLGKEFSRSYR
LRYSRDGRRWMDWKDRWGQEVISGNEDPGGVVLKDLGPPMVARLVRFYPRADRVMSVCLR
VELYGCLWRDGLLSYTAPVGQTMQLSEMVYLNDSTYDGYTAGGLQYGGLGQLADGVVGLD
DFRQSQELRVWPGYDYVGWSNHSFPSGYVEMEFEFDRLRSFQTMQVHCNNMHTLGARLPG
GVECRFKRGPAMAWEGEPVHHALGGSLGDPRARAISVPLGGHVGRFLQCRFLFAGPWLLF
SEISFISDVVNDSSDTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILIGCL
VAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPREPPP
YQEPRPRGTPTHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNTQAC
SGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRV
DFPRSRLRFKEKLGEGQFGEVHLCEVEDPQDLVTSDFPISVQKGHPLLVAVKILRPDATK
NARNDFLKEVKIMSRLKDLNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLENKVT
QGLPGDRESDQGPTISYPMLLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIA
DFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQ
PFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFSQLHR
FLADDALNTV
|
|
|
|---|
| BDBM347342 |
|---|
| n/a |
|---|
| Name | BDBM347342 |
|---|
| Synonyms: | 2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fluorophenyl)-N-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)acetamide | US9789100, Example 30 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H21F4N3O4 |
|---|
| Mol. Mass. | 467.4135 |
|---|
| SMILES | CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)c(F)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
