| Reaction Details |
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 | Report a problem with these data |
| Target | Protein ENL |
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| Ligand | BDBM50459722 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1767020 (CHEMBL4202267) |
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| Ki | 1430±n/a nM |
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| Citation |  Du, L; Grigsby, SM; Yao, A; Chang, Y; Johnson, G; Sun, H; Nikolovska-Coleska, Z Peptidomimetics for Targeting Protein-Protein Interactions between DOT1L and MLL Oncofusion Proteins AF9 and ENL. ACS Med Chem Lett9:895-900 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein ENL |
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| Name: | Protein ENL |
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| Synonyms: | ENL | ENL_HUMAN | LTG19 | MLLT1 | Protein ENL | YEATS domain-containing protein 1 | YEATS1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62068.50 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118046 |
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| Residue: | 559 |
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| Sequence: | MDNQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFP
KPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCE
KLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHG
SKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPK
EEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQ
KKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESN
SEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSS
SGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCS
KPEKILKKGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLF
SLDETTVRKLQSCLEAVAT
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| BDBM50459722 |
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| n/a |
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| Name | BDBM50459722 |
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| Synonyms: | CHEMBL4204545 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H66N8O9 |
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| Mol. Mass. | 778.9788 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(N)=O |r| |
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| Structure | 
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