| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin B |
|---|
| Ligand | BDBM50460494 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1769574 (CHEMBL4221686) |
|---|
| Ki | 123000±n/a nM |
|---|
| Citation |  Sosi?, I; Mitrovi?, A; ?uri?, H; Knez, D; Brodnik ?ugelj, H; ?tefane, B; Kos, J; Gobec, S Cathepsin B inhibitors: Further exploration of the nitroxoline core. Bioorg Med Chem Lett28:1239-1247 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cathepsin B |
|---|
| Name: | Cathepsin B |
|---|
| Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 37819.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_63102437 |
|---|
| Residue: | 339 |
|---|
| Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
|
|
|
|---|
| BDBM50460494 |
|---|
| n/a |
|---|
| Name | BDBM50460494 |
|---|
| Synonyms: | CHEMBL4228345 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H5N3O3 |
|---|
| Mol. Mass. | 215.165 |
|---|
| SMILES | Oc1ccc([N+]([O-])=O)c2ccc(nc12)C#N |
|---|
| Structure | 
|
|---|
Search and Browse
