| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin B |
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| Ligand | BDBM50460503 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1769566 (CHEMBL4221678) |
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| Ki | 12000±n/a nM |
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| Citation |  Sosi?, I; Mitrovi?, A; ?uri?, H; Knez, D; Brodnik ?ugelj, H; ?tefane, B; Kos, J; Gobec, S Cathepsin B inhibitors: Further exploration of the nitroxoline core. Bioorg Med Chem Lett28:1239-1247 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin B |
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| Name: | Cathepsin B |
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| Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 37819.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_63102437 |
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| Residue: | 339 |
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| Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
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| BDBM50460503 |
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| n/a |
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| Name | BDBM50460503 |
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| Synonyms: | CHEMBL4228082 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21N5O4S |
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| Mol. Mass. | 463.509 |
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| SMILES | Oc1c(cc([N+]([O-])=O)c2cccnc12)C(=O)NCC1CCN(CC1)c1nc2ccccc2s1 |
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| Structure | 
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