| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cGMP-dependent 3',5'-cyclic phosphodiesterase |
|---|
| Ligand | BDBM50460667 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1770030 (CHEMBL4222142) |
|---|
| IC50 | 38±n/a nM |
|---|
| Citation |  Stachel, SJ; Egbertson, MS; Wai, J; Machacek, M; Toolan, DM; Swestock, J; Eddins, DM; Puri, V; McGaughey, G; Su, HP; Perlow, D; Wang, D; Ma, L; Parthasarathy, G; Reid, JC; Abeywickrema, PD; Smith, SM; Uslaner, JM Indole acids as a novel PDE2 inhibitor chemotype that demonstrate pro-cognitive activity in multiple species. Bioorg Med Chem Lett28:1122-1126 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cGMP-dependent 3',5'-cyclic phosphodiesterase |
|---|
| Name: | cGMP-dependent 3',5'-cyclic phosphodiesterase |
|---|
| Synonyms: | CGS-PDE | Cyclic GMP-stimulated phosphodiesterase | Homo sapiens phosphodiesterase 2A (PDE2A) | NM_002599 | PDE2A | PDE2A_HUMAN | cGSPDE |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 105691.58 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O00408 |
|---|
| Residue: | 941 |
|---|
| Sequence: | MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI
SGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCN
GLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAV
EKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDL
DASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVV
EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD
EDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE
ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD
AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF
SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF
ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH
AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS
SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL
QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM
GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH
KFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
|
|
|
|---|
| BDBM50460667 |
|---|
| n/a |
|---|
| Name | BDBM50460667 |
|---|
| Synonyms: | CHEMBL4226404 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H17F4NO4S2 |
|---|
| Mol. Mass. | 487.488 |
|---|
| SMILES | CS(=O)(=O)c1cc(F)cc2n3CC[C@H](CC(O)=O)c3c(Sc3ccc(cc3)C(F)(F)F)c12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
