| Reaction Details |
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 | Report a problem with these data |
| Target | Plasmepsin IV [1-448] |
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| Ligand | BDBM50145786 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1771434 (CHEMBL4223546) |
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| IC50 | 130±n/a nM |
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| Citation |  Rasina, D; Stakanovs, G; Borysov, OV; Pantelejevs, T; Bobrovs, R; Kanepe-Lapsa, I; Tars, K; Jaudzems, K; Jirgensons, A 2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity. Bioorg Med Chem26:2488-2500 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasmepsin IV [1-448] |
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| Name: | Plasmepsin IV [1-448] |
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| Synonyms: | PLM4_PLAF7 | PMIV | Plasmepsin 4 (PM-IV) |
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| Type: | Enzyme |
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| Mol. Mass.: | 50925.00 |
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| Organism: | Plasmodium falciparum |
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| Description: | Q8IM16[1-448] |
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| Residue: | 448 |
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| Sequence: | MALTVKEEEFSNTLIKNASAFDRLKLGNLKNLKIQKKLQFLYLILFVLITGVFFFFLIGN
FYSHRKLYQVIKNTKHTTIGFKIDRPHDKVLSSVLKNKLSTYVKESFKFFKSGYAQKGYL
GSENDSIELDDVANLMFYGEGQIGTNKQPFMFIFDTGSANLWVPSVNCDSIGCSTKHLYD
ASASKSYEKDGTKVEISYGSGTVRGYFSKDVISLGDLSLPYKFIEVTDADDLEPIYSGSE
FDGILGLGWKDLSIGSIDPVVVELKKQNKIDNALFTFYLPVHDKHVGYLTIGGIESDFYE
GPLTYEKLNHDLYWQIDLDIHFGKYVMQKANAVVDSGTSTITAPTSFLNKFFRDMNVIKV
PFLPLYVTTCDNDDLPTLEFHSRNNKYTLEPEFYMDPLSDIDPALCMLYILPVDIDDNTF
ILGDPFMRKYFTVFDYEKESVGFAVAKN
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| BDBM50145786 |
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| n/a |
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| Name | BDBM50145786 |
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| Synonyms: | CHEMBL3763523 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H33N3O2 |
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| Mol. Mass. | 515.6447 |
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| SMILES | Nc1nc2cc(ccc2c(=O)n1C[C@@H]1CC[C@@H](O1)c1ccccc1)-c1ccc(CCCc2ccccc2)cc1 |r| |
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| Structure | 
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