Reaction Details |
| Report a problem with these data |
Target | Plasmepsin II |
---|
Ligand | BDBM50461471 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1771433 (CHEMBL4223545) |
---|
IC50 | 500±n/a nM |
---|
Citation | Rasina, D; Stakanovs, G; Borysov, OV; Pantelejevs, T; Bobrovs, R; Kanepe-Lapsa, I; Tars, K; Jaudzems, K; Jirgensons, A 2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity. Bioorg Med Chem26:2488-2500 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Plasmepsin II |
---|
Name: | Plasmepsin II |
Synonyms: | Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II |
Type: | Enzyme |
Mol. Mass.: | 51482.09 |
Organism: | Plasmodium falciparum |
Description: | P46925 |
Residue: | 453 |
Sequence: | MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYE
NVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKT
NYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKH
LYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYT
ASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEER
FYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDV
IKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPV
PTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
|
|
|
BDBM50461471 |
---|
n/a |
---|
Name | BDBM50461471 |
Synonyms: | CHEMBL4225481 |
Type | Small organic molecule |
Emp. Form. | C21H21N3O4 |
Mol. Mass. | 379.4091 |
SMILES | Nc1nc2cc(cc(CC(O)=O)c2c(=O)n1CC1CCCO1)-c1ccccc1 |
Structure |
|